|Carl Johan Sundberg||Molecular Exercise Physiology||Preclinical/Clinical||Physiology & Pharmacology (FyFa)||[email protected]||Regular physical activity provides health benefits for men and women of all ages, ranging from reduced risks of cardiovascular diseases, diabetes and certain types of cancer, to enhanced skeletal muscle capacity. These benefits can all be ascribed to the adaptations that gradually occur with repeated exercise.|
Physical training affects a multitude of tissues throughout the human body. For instance, maximal cardiac output increases, the amount of body fat decreases, glucose control is improved and blood pressure is reduced. Our research mainly focuses on the exercise-induced mechanisms that take place in skeletal muscle and adipose tissue in healthy individuals, elite athletes and in patients with breast cancer.
|Olle Kämpe||Experimental Endocrinology||Preclinical/Clinical||Medicine Solna (MedS)||[email protected]|| Our research group uses rare and homogenous disorders as models in order to better understand autoimmunity at the B and T cell level, e.g. Addison's disease with complex inheritance and monogenic disorders such as APS-1 with mutations in the AIRE gene with defects in central tolerance and IPEX with mutations in the FOXP3 gene lacking T regulatory cells. We have made the original identification of autoantibodies against e.g. 21-hydroxylase in Addison’s disease, side-chain cleavage in autoimmune premature ovarian insufficiency and NALP5 in autoimmune hypoparathyroidism, today all used in clinical routine world wide.||1||Both||Yes|
|Anna-Karin Welmer||Medical group||Clinical||Neurobiology, Care Sciences, and Society (NVS), Aging Research Center||[email protected]||Anna-Karin’s primary area of research interest is the epidemiology of physical function, disability and falls in older persons. Currently she is working with the following research lines:|
1.Exploring the complex interactions between biological, demographic, and social factors; chronic diseases; and lifestyle that may explain the development of disability in old age.
2.The European MPI (Multidimensional Prognostic Indices) project, which aims to use the MPI to predict survival in older individuals.
3.The body-mind connection.
4.The VR-financed project: “Thinking, moving, and falling: Early detection of fall-prone phenotypes as targets for primary interventions—a translational study”. The goal of this project is to enable early detection of fall risk in older adults who can be targets for primary interventions.
|Gerald Cooray||Neuro Hyllienmark||Clinical||Clinical Neuroscience (CNS)||[email protected]||Mathematical modelling of cortical activity in epilepsy. Our main interest is in increasing the understanding of the physiology of the epileptic brain. We study the pathophysiological activity during epileptic seizure activity with intention of modelling and understanding seizure initiation and spread. Moreover, we are also investigating the effect of chronic electrical stimulation over epileptic regions of the brain with intent on understanding the physiological changes that occur which have shown to reduce seizure activity. We use neurophysiological recordings in patients with epilepsy using both non-invasive and invasive EEG and non-invasive MEG.||1-2||Both||Maybe||Some knowledge in mathematics or background in the technical sciences would be useful for any interested student.|
|Karin Broberg||Metaller och hälsa||Preclinical/Clinical||Environmental Medicine (IMM)||[email protected]||Vi undersöker hur metaller i miljön, tex i dricksvatten och föda, påverkar risk för sjukdom. Vi har ett särskilt fokus på exponering tidigt i livet och hur det påverkar barnets utveckling. Vi studerar olika mekanismer för metalltoxicitet: hormonella, epigenetiska, genetiska och metabola.||1-2||Both||Maybe|
|Kajsa Müllersdorf||–||Clinical||Learning, Informatics, Management and Ethics (LIME)||[email protected]||Using a knowledge based decision support to collect and analyze patient medical history. Goal is to improve management of care and clinical outcome. Ongoing study at Danderyds Sjukhus in collection of data from patients presenting with chest pain at the emergency.||>2||Both||Yes|
|Anna Krook||Integrative physiology||Preclinical||Physiology & Pharmacology (FyFa)||[email protected]||Det övergripande syftet med forskningen inom integrativ fysiologi är att upptäcka och definiera riktpunkter som är viktiga inom metabola sjukdomar, till exempel vid nedsatt glukos homeostas och typ 2-diabetes mellitus.|
Forskargruppen fokuserar på att identifiera de underliggande mekanismer som styr olika metabola sjukdomar. I synnerhet, men inte enbart med fokus på, insulinresistens i skelettmuskulatur.
Vi har utvecklat en unik metod för att studera human muskel, och var först med att identifiera vilka molekylära steg som är nedreglerade i insulinsignaleringskedjan i muskel från personer med typ 2-diabetes mellitus. Många försök utförs också på odlad human muskel, både från friska personer och från personer med diabetes för att kartlägga sjukdomsbilden på molekylär nivå.
Ett annat viktigt område för gruppens forskning är effekten av fysisk aktivitet/muskel kontraktion. Fysisk aktivitet ökar muskelns insulinkänslighet, och kan förbättra glukosmetabolismen hos personer med diabetes.
Please see http://ki.se/en/fyfa/integrative-physiology
|1-2||Both||Maybe||Longer term commitments are prioritised|
|Annika Scheynius||own||Preclinical/Clinical||Department of Clinical Science and Education, Karolinska Institutet, and Sachs' Children and Youth Hospital, Södersjukhuset||[email protected]||Mechanisms behind allergy|
Allergic diseases are one of the commonest causes of chronic ill health causing personal suffering and increasing socio-economic and health care costs. There is a great need for novel initiatives within health care for prevention, specific diagnosis and treatment. My overall aim to increase understanding of the mechanisms behind allergy is: 1) to characterize the role of environment and lifestyle, including in utero environment, with a focus on host-microbe, epigenetic and gene-environment interactions in the development of allergy, and 2) to elucidate mechanisms by which allergens interact with our immune system, to provide knowledge on how the body´s own regulatory mechanisms can be used for prevention and treatment. The project is performed in a cross-disciplinary international network with front-line competence spanning from clinical and epidemiological research, immunology, microbiology, molecular and cell biology, metagenomics and epigenetics. This project will result in better understanding how to disentangle risk from protective factors in the development of allergic diseases leading to novel strategies for prevention and treatment and create diagnostic tools to discover new subgroups of patients.
|Gert Helgesson||Stockholm Centre for Healthcare Ethics||Preclinical/Clinical||Learning, Informatics, Management and Ethics (LIME)||[email protected]||We are doing research in medical ethics, which includes empirical and theoretical (philosophical) work. The main applied fields are healthcare ethics and medical research ethics.||1-2||Both||No||It helps for students coming to us if they are "philosophically inclined", for instance interested in ethical issues. Also a plus if they have had some courses in philosophy (but not required). Our empirical research mainly consists in working with questionnaires and interviews.|
|Jan-Bernd Stukenborg||Pediatric Endocrinology Unit; Nordfertil Research Lab Stockholm||Preclinical||Women’s and Children’s Health (KBH)||[email protected]||Fertility preservation techniques for children suffering gonadotoxic treatments (e.g. studies on ex vivo cultures of gonadal tissue; in vitro differentiation of pluripotent stem cells; studies on gonadal development)||1-2||The semester||Maybe|
|Per Uhlén||Uhlén Lab||Preclinical||Department of Medical Biochemistry and Biophysics (MBB)||[email protected]||Our research group is studying developmental and cancer related processes in various types of cells. The biological platforms that we are applying are tissue slices, primary cell cultures, cell lines and stem cells. To study the processes of cell division, cell differentiation, and neural migration/networking we are applying state-of-the-art imaging techniques and modern genetic tools, such as single-cell sequencing and transgenic animals. Our focus is to shed light on the intracellular cell signaling mechanisms that regulate these vital processes for development and disease.||1-2||Both||Yes|
|Yihai Cao||Yihai Cao||Preclinical||Microbiology, Tumor and Cell biology (MTC)||[email protected]||Preclinical angiogenesis research in obesity and cancer||1-2||Both||No|
|Tie-Qiang Li||Functional imaging||Preclinical/Clinical||Clinical Science, Intervention and Technology (CLINTEC)||[email protected]||Neuroimaging of the human brain||1-2||Both||Maybe|
|Per Södersten||applied neuroendocrinology||Preclinical/Clinical||Neurobiology, Care Sciences, och Society (NVS)||[email protected]||Recovery from under- and overweight by machine – the mind is in the jaw – chewing for brain development – virtual eating||>2||The semester||Maybe||mandometer.com. students are wonderful|
|Amaia Calderón-Larrañaga||Aging Research Center||Clinical||Neurobiology, Care Sciences and Society (NVS)||[email protected]||My research focuses on the study of environmental and behavioural determinants of health changes in the older population using data from the Swedish National Study on Aging and Care (SNAC).||1-2||Both||Maybe|
|Tina Dalianis||TinaDalianis/AndersNäsman/Cinzia Bersani||Preclinical/Clinical||Oncology-Pathology (OnkPat)||[email protected]||Studies of human papillomavirus and other tumor viruses in cancer||1-2||Both||Maybe||We are presently moving labs, so it may take a semester before we can receive students.|
|Ganesh Acharya||Head of the Division of Obstetrics and Gynecology, CLINTEC||Preclinical/Clinical||Clinical Science, Intervention and Technology (CLINTEC)||[email protected]||Placental Biology, Pregnancy complications, Fetal Medicine||1||The semester||No|
|Agneta Nordberg||Translational Alzheimer Neurobiology||Preclinical/Clinical||Neurobiology, Care Sciences, och Society (NVS)||[email protected]||Translational reasearch in alzheimer´s disease and other related dementia disorders with the aim to develop and use PET imaging tracers to be studiesi autopsy large bran sectios (autoradography) as well as in living patients from presymtomatic stage and whole diease progression.||1-2||The semester||Maybe|
|Lalit Kumar Parameswaran Grace||Kristina Gemzell Danielsson||Preclinical||Women’s and Children’s Health (KBH)||[email protected]||1. Stem cells in endometrial regeneration. 2. Endometriosis and endometriosis associated cancer. 3. Endometrial receptivity and human embryo implantation||1-2||The semester||No|
|Richard Rosenquist Brandell||Clinical Genetics||Preclinical/Clinical||Molecular Medicine and Surgery (MMK)||[email protected]||Cancer genomics||1-2||The semester||Maybe|
|Anthony Wright||Kliniskt forskningscentrum, gene regulation group||Preklinisk||Laboratory Medicine (LABMED)||[email protected]||lymfomutveckling och utveckling av resistens mot läkemedel||1-2||Terminen||Nej|
|Jesper Lagergren||Upper Gastrointestinal Surgery||Preclinical/Clinical||Molecular Medicine and Surgery (MMK)||[email protected]||The research examines diseases and surgical procedures of the oesophagus and stomach, with a focus on causes, prevention and treatment of oesophageal cancer and conditions associated with this tumour, i.e. Barrett's oesophagus, gastro-oesophageal reflux and obesity.||1-2||Both||Maybe||The research group contains several potential supervisors, and if a medical student is accepted to work with us, he or she will be supervised by other researchers than the group leader (Jesper Lagergren).|
|Weimin Ye||Weimin Ye||Preclinical/Clinical||Medical Epidemiology and Biostatistics (MEB)||[email protected]||We work on etiology, early detection, and prognosis of head & neck cancer and upper gastrointestinal tract cancers.||1-2||Both||Maybe|
|Debora Rizzuto||Aging Research||Preclinical||Neurobiology, Care Sciences and Society (NVS)||[email protected]ki.se||My research activity focuses on investigating the most relevant factors that lead to longer and healthier life. Using a life-course perspective I am exploring the role of health status, lifestyle factors, social environment, and genetic background on late-life health and survival.||1||The semester||No|
|Christopher Hübel||CEDI – Centre for Eating Disorders Innovation||Preclinical/Clinical||Medical Epidemiology and Biostatistics (MEB)||[email protected]||At the Centre for Eating Disorders Innovation (CEDI) we are dedicated to applying novel and emerging methodologies and technologies to elucidate causal mechanisms underlying eating disorders. Our ultimate goal is to rigorously apply findings from genetic, biological, and environmental risk investigations to refine and personalize detection, prevention, and treatment of eating disorders.||1-2||Both||Maybe|
|Nele Brusselaers||Centre for Translational Microbiome Research||Clinical||Microbiology, Tumour and Cell biology (MTC)||[email protected]||Clinical epidemiology||1||The semester||No|
|Ewa Ehrenborg||Per Eriksson||Preclinical/Clinical||Medicine Solna (MedS)||[email protected]||ROLE OF AUTOPHAGY IN ATHEROSCLEROSIS |
Recently, a link between lipid droplet (LD) associated proteins, reverse cholesterol transport and autophagy has been shown in mice, suggesting an important role in the pathogenesis of atherosclerosis. Autophagy is a highly conserved self-protecting process as cellular response to stress, in which cellular components are self-consumed and recycled for downstream metabolism. Misfolded proteins and organelles e.g. mitochondria and LDs are selective substrates of macroautophagy whereas specific LD associated proteins are substrates for chaperone-mediated autophagy (CMA). The most abundant LD protein for metabolically active cells is perilipin 2 (PLIN2) and its degradation by CMA seems to be dependent on different drugs.
To explore the function of PLIN2 in humans, we employ a genetic strategy where we study functional genetic variants with different approaches ranging from detailed cell and molecular biology to genetic epidemiological analyses of cardiovascular disease.
We are also characterizing the role of autophagy markers in relation to atherogenesis and plaque vulnerability for putative therapeutic purposes. Analyses in progress of central autophagy proteins show that they are mainly expressed in vulnerable regions of human carotid plaques. Interestingly, plaque autophagy appears to be influenced both by metabolic status and drug treatment. In these studies we also investigate human tissues originating from different biobanks as well as atherogenic mice models.
|Anton Lager||PRIME Health||Preclinical/Clinical||Public Health Sciences (PHS)||[email protected]||Public health epidemiology with focus on major diseases and determinants. Head of Unit, Health Situation and Care Needs Analysis, Centre for Epidemiology and Community Medicine (CES, SLL). Topics include: GBD, geographical health differences, epidemiological surveillance, incident diabetes type 2, mental health among children and youth, eating disorders, obesity, physical activity, labour market position among young people, IQ and emotional skills, education's effect on IQ/emotional control/dementia/mortality, equal access to health care, and the association between parental income and life expectancy.||>2||Both||Yes|
|Monika Ehnman||Arne Östman||Preklinisk/Klinisk||Oncology-Pathology (OnkPat)||[email protected]||Translational research studies on soft-tissue sarcoma with a focus on how tumor cells interact with infiltrating stroma cells in a context-dependent manner. Ongoing projects deal with immune cell infiltration and how stroma cells are molecularly reprogrammed in the tumor microenvironment during tumor progression. We are particularly interested in the platelet-derived growth factor family of growth factors as sarcoma drivers and drug targets.||1-2||Båda||Kanske||Student projects will be tailor-made based on previous experience, but can include immunostaining and microscopy or 3D cell culture and gene expression analysis by qPCR or analysis of available data sets.|
|Elias Arnér||Division of Biochemistry, Arnér group||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||We work on selenoproteins and redox control of cell function, with a special focus on molecular mechanisms and applications in cancer therapy.||1-2||Both||Maybe|
|Lars Rydén||Lars Rydéns grupp för Diabetesforkning/Prevention||Clinical||Medicine Solna K2 (MedS)||[email protected]||Vi bedriver kliniskt inriktad forskning som syftar till att minska risken för hjärt-kärlsjukdom i samband med diabetes ffa av typ 2. Kliniska prövningar, stora som små, Europabaserade undersökningar om vårdkvalitet ochmetider för screening för att spåra individer med prediabetes eller tidigare okänd diabetes ingår. Gruppen är produktiv och internationellt mycket väl förankrad med många nationella och internationella samarbetspartners.||1-2||Both||Yes|
|Agneta Richter-Dahlfors||Swedish Medical Nanoscience Center||Preclinical||Neuroscience (Neuro)||[email protected]||At the Swedish Medical Nanoscience Center we promote efficient integration of cutting edge technologies and medical research. We aim to solve biological and medical problems, focussing particularly on bacterial infection, using various kinds of nano-technological approaches.||1-2||Both||Maybe|
|Keira Melican||Swedish Medical Nanoscience Center||Preclinical||Neuroscience (Neuro)||[email protected]||In my group we are studying 'Tissue Microbiology'. We have projects available focussing on Staphylococcus bacteria in a humanised model of skin infection/colonisation. We use a number of techniques including intravital microscopy.||1-2||Both||Maybe|
|Pär Nordlund||Pär Nordlund||Preclinical||Oncology-Pathology (OnkPat)||[email protected]||The group has developed a novel strategy for discovering clinical biochemical biomarkers that bear the potential to improve drug therapies for different cancers. The technology, Cellular Thermal Shift Assay (CETSA), allows for the direct quantification of biochemical changes of activation states of proteins in patient samples.||1-2||Both||No|
|Mattias Günther||Risling||Preclinical/Clinical||Neuroscience (Neuro)||[email protected]||Experimentell traumatologi, fysiologistudier på gris, men även cellkulturer||1-2||Both||Maybe|
|Ning Xu Landén||N Xu Landén's group||Preclinical||Medicine Solna (MedS)||[email protected]||Both chronic non-healing wounds and psoriasis are major and rising health and economic burdens worldwide and lack of effective treatment. Investigation of the role of regulatory RNAs, for example microRNA and long non-coding RNAs, represents an emerging concept, and constitutes a promising area for pharmaceutical intervention. The goal of our laboratory is to unravel the role(s) of regulatory RNAs in skin wound healing and in psoriasis. Moreover, we aim to translate basic scientific findings into therapeutic interventions for patients.||1-2||Both||Maybe||More information can be found at https://www.xulandenlab.com/|
|Petter Brodin||Petter Brodin||Preclinical/Clinical||Medicine Solna (MedS)||[email protected]||Systems Immunology, newborn immune system development, computational biology||1||Both||Maybe|
|Peder Olofsson||Olofsson||Preclinical/Clinical||Medicine Solna (MedS)||[email protected]||Neural control of vascular inflammation||1-2||Both||Maybe|
|Elin Rönnberg Höckerlind||Gunnar Nilsson||Preclinical||Medicine Solna Immunology and Allergy (MedS)||[email protected]||Mast cells are strongly implicated in the pathogenesis of asthma. However, the role of different mast cell populations and mediators in the pathology of asthma remain unclear. In this study, we hypothesize that there is a phenotypical and functional heterogeneity among human lung mast cells that play a pivotal role for the features of asthma and we aim to characterize the heterogeneity in unbiased ways. We will perform single cell RNA sequencing on human lung mast cells, and we have used a flow cytometry panel of 334 different markers and have found novel and interesting markers with a high degree of expression variability within the mast cell population. Co-staining of identified markers, from the 2 different approaches, will be analyzed to define novel mast cell subpopulations that will be isolated and investigated for their differences in functionality. We have identified expression of several frizzled receptors. The agonists to the Frizzled receptors are Wnts and Wnt signaling is primarily involved in embryonic development, proliferation, differentiation and tissue damage/repair. Recent findings have implicated Wnt pathways in critically regulating inflammatory responses, especially in asthma. The role(s) of Wnt signaling in mast cells is however unknown and to further investigate this we will first the in vitro response of mast cells too different Wnts and look at receptor activation, proliferation, differentiation, reactivity and cytokine production of the mast cells.||1-2||The semester||No|
|Liv Eidsmo||Eidsmo||Preclinical/Clinical||Medicine Solna (MedS)||[email protected]||Jag är hudläkare och immunolog. Genom studier av hudens T celler försöker min grupp hitta mer effektiva behandlingar av hudsjukdomar som vitiligo och psoriasis. Målet är att öka kunskap om immunsystemet i frisk och sjuk vävnad. Det är oändligt spännande att få vara del av en forskningsrörelse som förändrar synen på grundläggande immunologi genom att flytta fokus från blod och in vitro försök till humana vävnader. Man kan också söka på våra senaste studier och pressnytt från ki.se i våras för att lära mer om vårt arbete.||1-2||The semester||Maybe||Som gammal LäFo ställer jag förstås upp men håller på med rätt krävande grundforskning – det är hur kul som helst men man måste vara intresserad på riktigt och inte bara skaffa meriter inför framtida anställningar.|
|Lisa Thorell||Thorell||Preclinical/Clinical||Clinical Neuroscience (CNS)||[email protected]||The main research focus in my group is Attention Deficit Hyperactivity Disorder (ADHD) in children, adolescence and adults. More specifically, we investigate neuropsychological functioning (i.e. deficits in working memory, inhibitory control, switching, planning, and emotion regulation) and how these functions are related to ADHD and to daily life functioning (e.g., social relations, academic functioning). We are also involved in a few treatment studies, primarily regarding cognitive training in children and psychosocial interventions in adult ADHD. In addition to this line of research, we also do longitudinal research where we follow children across several years to investigate early predictors of ADHD, as well as academic and social functioning. Finally, we are involved in the EXPRESS-study, a large multi-center study investigating psychological adjustment in extremely preterm children (i.e., children born week 23-26).||1-2||The semester||Maybe|
|Eduardo Villablanca||Mucosal Immunology group (Villablanca)||Preclinical||Medicine Solna (MedS)||[email protected]||We try to understand the mechanism underlying immune-mediated intestinal disorders||1-2||Both||No|
|Anna Fogdell-Hahn||Klinisk Neuroimmunologi||Preclinical/Clinical||Clinical Neuroscience (CNS)||[email protected]||Immunogenicitet hos läkemedel, tester för anti-läkemedelsantikroppar, multipel skleros, humant herpesvirus 6, http://www.cmm.ki.se/group/klinisk-immunologi-fogdell-hahn-2/||1||The semester||No|
|Ingrid Kockum||Genetic epidemiology of multiple sclerosis||Preclinical/Clinical||Clinical Neuroscience (CNS)||[email protected]||Our research group studies genetic epidemiology of multiple sclerosis (MS), including different measures of outcome of disease including biomarkers for disease. We are studying interaction between lifestyle exposures affecting risk of MS and genetic risk factors. We are also studying the genetic control of immune response to viruses that affect the risk of developing MS and potential autoantigens for MS.||1-2||Both||Maybe|
|Cecilia Boldemann||Preclinical||Public Health Sciences (PHS)||[email protected]||Synergetic mpact of outdoor physical environment upon children's health||1||The semester||Maybe||I'm not a clinician but, my field of expertise is public health sciences, my "patients" are communities|
|Lars Jakobsson||Jakobsson||Preclinical/Clinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||Our aim is to find new ways of manipulating the blood or the lymphatic vascular system to treat diseases such cancer, stroke, diabetes complications and genetic vascular malformation . We use genetically modified mice in which we can delete genes in a subpopulation of cells that also can be identified by fluorescent reporters. We apply advance microscopy (live of static), in living mice and whole fixed organs. We apply a flurry of technologies including single-cell sequencing. Please see http://ki.se/en/mbb/lars-jakobsson-group for more info||1||Both||Maybe|
|Annelie Falkevall||Ulf eriksson||Preclinical||Medical Biochemistry and Biophysics (MBB) – division of vascular biology||[email protected]||Role of VEGF-B and lipotoxicity in diabetes and diabetic complications||1||The semester||No|
|Roman Zubarev||Kemi I||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||proteomics; mass spectrometry; chemical proteomics; drug target identification; ageing; Alzheimer's disease; cancer cell death; origin of life; isotopic resonance||>2||Both||Maybe||Need motivated, self-driven students who are interested in science|
|Jens Hjerling Leffler||Hjerling-Leffler Group||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||Molecular Neuroscience, single-cell sequencing, electrophysiology, mouse genetics. Please visit http://www.hjerling-leffler-lab.org for more information||1||Both||Maybe||We are looking for committed student who wants to both learn basic techniques providing technical support to the lab but also take active part in projects.|
|Ana Teixeira||Ana Teixeira Group||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||Nanomedicine (teixeiralab.com)||1||Both||Maybe|
|Maria Sabater Lleal||Cardiovascular Medicine||Preclinical||Medicine solna (MedS)||[email protected]||It is now every time more common to use the so called “organ-on-a-chip” structures to study in vitro the function and behaviour of different diseases and cell-mechanisms in a set-up that is more close to the physiological conditions that the more traditional in vitro cell work. The organ-on-a-chip are microchips that recapitulate the microarchitecture and functions of living organs, such as the lung, heart, and intestine. |
The aim of the project is to establish a microchannel system that can mimic a vessel, and that can be used to assess the effect of particular candidate genes, flow conditions, or blood components on the endothelial cell, specially referring to platelet adhesion and thrombus formation.
|Katja Petzold||Petzold||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||We work with structural biology/Biophysics of RNA and try to understand how RNA moves in order to perform its biological function||1-2||Both||No|
|Nicola Crosetto||https://bienkocrosettolabs.org||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||We are interested in understanding how the 3D architecture of the genome shapes the higher propensity of DNA to break in certain regions. In particular, we are interested in understanding how chromatin dynamics throughout the cell cycle and the interplay between DNA replication and transcription are linked to the formation of DNA double-strand breaks (DSBs) along the genome. We have pioneered the first method, BLESS, for mapping the genomic location of DSBs (Crosetto et al, Nat Meth 2013), and recently we have developed a powerful improvement, BLISS, which allows quantitative genome-wide analysis of DSBs even in low-input samples (Yan et al, Nat Commun 2017). We combine DSB detection methods with state-of-the-art chromosome conformation capture assays (HiC), high-resolution DNA and RNA in situ fluorescence hybridization methods (Bienko, Crosetto et al, Nat Meth 2013), and methods newly developed in our lab that interrogate the radial positioning of chromosomes in the cell nucleus.||1-2||Both||Maybe||Only highly motivated students are encouraged to apply|
|Paul Gerdhem||Enheten för ortopedi och bioteknologi||Klinisk||Clinical Science, Intervention and Technology (CLINTEC)||[email protected]||Kliniska studier; observationsstudier och randomiserade kontrollerade studier inom ryggsjukdomar. Biokemiska och genetiska studier på kliniska material inom ryggsjukdomar, speciellt skolios||1||Terminen||Ja|
|Gabriel Sandblom||Surgery||Clinical||KI SöS||[email protected]||Reseach mainly focused on management of biliary pancreatitis, gallstone disease and abdominal wall surgery. Clinical research based on patient registers, retrospective patient record reviews and randomised controlled trials.||1-2||Both||Maybe|
|Konstantinos Ampatzis||Ampatzis||Preclinical||Neuroscience (Neuro)||[email protected]||We are working on neuroplasticity mechanisms that allow the neuronal networks to be flexible and adaptable in light to new environmental demands. In our lab we focus on the vertebrate spinal networks controlling locomotion and on cerebellum involvement on motor and non-motor (cognitive, memory) functions.||1-2||Both||Maybe|
|Eva Hedlund||Hedlund lab||Preclinical||Neuroscience (Neuro)||[email protected]||We try to elucidate mechanisms of neuronal vulnerability and resistance in neurodegenerative disease, with a particular focus on amyotrophic lateral sclerosis||1-2||The semester||Maybe|
|Arne Holmgren||Biokemi/Arne Holmgren||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||Redox biologi||1-2||The semester||Maybe|
|Dasiel Oscar Borroto Escuela||Fuxe lab||Preclinical||Neuroscience (Neuro)||[email protected]||We are primarily focused on understanding the molecular integration of signals in the brain via receptor-receptor interaction in the heteroreceptor complexes and its functional effects . We are also interested in whether alterations in specific heteroreceptor complexes and their receptor-receptor interactions are associated with and/or play a role in pathogenetic mechanisms contributing to brain disease development, inter alia Parkinson's disease, schizophrenia, addiction and depression. We are very excited by the tremendous potential of the field of heteroreceptor complexes in the CNS and their receptor-receptor interactions. They offer novel targets for treatment of psychiatry and neurological disorders.||>2||Both||No||We have our own Leica confocal microscope SP5, and also several cutting-edge equipments (Polar Optima). We have grants to cover the experiments, however, we do not have financial support right now to cover stipends or salaries.|
|Andreas Kardamakis||Kardamakis||Preclinical||Neuroscience (Neuro)||[email protected]||We are a newly established research team that aims to understand how the brain implements computations that link sensory inputs to motor actions with particular focus on visual-motor processing within the superior colliculus and its interaction with the basal ganglia and neocortex for the control of gaze movements. To achieve this goal, we will take an innovative that combines in vivo electrophysiology, optogenetics and mouse genetics with a virtual-reality system to simulate a visual environment during spatial navigation.||1||Both||Maybe|
|Daniela Enache||Neurogeriatrics||Clinical||Neurobiology, Care Sciences, och Society (NVS)||[email protected]||depression and cognitive disorders||1||The semester||No|
|Helena Karlström||Karlström||Preclinical||Neurobiology, Care Sciences, och Society (NVS)||[email protected]||Cell and animal models on inherited form of vascular dementia (CADASIL). Molecular, biochemical work to understand the mechanisms behind the disease. Development of an active and passive vaccination approach as well as diagnostic assay to monitor disease progress and treatment efficacy.||1||Both||Maybe|
|Chris Grigsby||Molly Stevens||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||We use biomaterials to direct and promote the reprogramming of somatic cells to functional neurons.||1||Both||No|
|Daniel Ferreira||Imaging Group (http://ki.se/en/nvs/imaging-research)||Clinical||Neurobiology, Care Sciences, och Society (NVS)||[email protected]||Neuroimaging, cognition and CSF biomarkers in healthy aging and neurodegenerative disorders (http://ki.se/en/people/danife)||1-2||Both||Maybe|
|Robert Månsson||Månsson lab||Preclinical/Clinical||Laboratory Medicine (LABMED)||[email protected]||My laboratory focuses on epigenetics in normal B-cell development and chronic lymphocytic leukemia mainly. Our studies of normal B-cell development are mainly focused around understanding gene regulation in the different stages of maturation from stem cells to mature B-cells. The CLL studies on the other hand try to merge CLL genetics and epigenetics to identify relevant mutations that do not directly alter the function of a gene but rather its regulation.|
The basis for the CLL project is our interaction with the Hematology Center at Karolinska Sjukhuset and the CLL biobank that we are building up.
|1-2||Both||Maybe||We're not interested in hosting students for short periods. If they like to join I'd like to see that they commit and at least spend a year part time.|
|Molly Stevens||Molly Stevens' Group||Preclinical||Medical Biochemistry and Biophysics (MBB)||[email protected]||The ability to regenerate damaged tissue is one of the great challenges in the fields of tissue engineering and regenerative medicine. Our goal is to study the fundamental science of cell-material interactions and apply this knowledge to the design of biomaterials that translate into clinical solutions||1-2||Both||No|
|Alina Castell||Lars-Gunnar Larsson/Alina Castell||Preclinical||Microbiology, Tumor and Cell biology (MTC)||[email protected]||Targeting the MYC oncoprotein in childhood cancer|
This project is about identifying, characterizing and developing inhibitors targeting the MYC oncoprotein in cancer, in particular childhood cancer. The project includes validation of MYC inhibitors in tumor cell systems using various assays such as cell growth assays, coimmunoprecipitation and protein complementation assays.
|Per Svenningsson||Translationell Neurofarmakologi särsklit Parkinsons sjukdom||Preclinical/Clinical||Clinical Neuroscience (CNS)||[email protected]||Parkinson´s disease (PD) is a common neurodegenerative disorders with a largely unknown etiology. The next breakthrough in the treatment of Parkinsons disease (PD) will be aimed at interference or blockade of disease progression, based on insights into the underlying pathogenic process. The development of this new generation of disease-modifying drugs is hampered by the lack of adequate diagnostics and biomarkers that reflects early signs of disease. The motor signs of PD are often preceded by non-motor symptoms including depression, anosmia, REM sleep disorder and constipation.|
It is important to develop an improved knowledge of these clinical signs of early PD as neuroprotective and restorative therapies for PD would ideally be offered at an early stage to effectively modify disease progression. The laboratory develops cell and animal models to mimic the progressive disease progression in PD. Biochemical, histological, pharmacological, molecular biological and behavioral techniques are used in these studies.
In clinical studies with patients, clinical ratings, biochemical and imaging (PET and MRI) analyses are being made. A special emphasis is placed on non-motor symptoms of PD and the identification of biomarkers. The information is transferred to a newly developed PD quality register. The research team also studies the pathophysiology of unipolar depression in animal models as well as in patient samples. In addition to PD, other movement disorders including Huntington's disease and ataxia are studied.
|Ola Hermanson||Hermanson lab||Preclinical||Neuroscience (Neuro)||[email protected]||Molecular mechanisms of neural development and tumorigenesis||1-2||Both||Maybe|
|Johan Askling||Clinical Epidemiology Section||Clinical||Medicine Solna (MedS)||[email protected]||Clinical epidemiological research (registers, clinical cohorts, large datasets) on clinically relevant research questions, such as studies on drug safety, co-morbidities, trreatment outcomes, but also risk factors for disease onset, mainly in chronic inflammayory diseases||>2||The semester||Maybe|
|Sean Rudd||Thomas Helleday||Preclinical||Science For Life Laboratory, Medical Biochemistry and Biophysics (MBB SciLifeLab)||[email protected]||Our research is focused upon improving existing treatments for cancer patients. Central to this work is the enzyme SAMHD1, which we identified as a therapeutic barrier to an important group of anti-cancer drugs (Herold & Rudd et al., Nat. Med. 2017; Rudd et al., Mol. Cell. Oncol. 2017). Continuing from this study we wish to further define and, if possible, exploit this role of SAMHD1 by developing small molecule inhibitors of this enzyme. Practically, this project entails working in a small interdisciplinary team using an array of different techniques, including biochemical, biophysical, and cell-based assays.||1-2||Both||Maybe|
|Pontus Hedberg||Mats Wahlgren||Preclinical/Clinical||Microbiology, Tumor and Cell biology (MTC)||[email protected]||Our research is aiming at exploring the role of the histo-blood group ABO system in the pathogenesis of severe Plasmodium falciparum malaria. This is done by in vitro-cultivation of Plasmodium falciparum laboratory strains and patient isolates and assessing their rosetting and cytoadherence (important virulence factors in P. falciparum) characteristics in blood/endothelial cells from patients with different ABO blood groups (BgO, BgA, BgB, BgAB) and subgroups (e.g. A1 vs A2). In the future, the research project will continue to explore this relationship by collecting epidemiological data in malaria-endemic settings.||1-2||Both||No|
|Håkan Källmen||Källmen/Gripenberg||Clinical||Clinical Neuroscience (CNS)||[email protected]||Evaluation of Housing First, a municipal housing program for homeless, regarding health, substance abuse and recovery.||1-2||The semester||No||students are expected to participate in the whole process of research, from data collection, data entrance, to reporting results.|
|Andrea Carmine Belin||Carmine Belin||Preclinical||Neuroscience (Neuro)||[email protected]||Increase the understanding of the pathophysiology of neurological disorders with a focus on and neurovascular disorders such as cluster headache by identifying, characterizing and modelling genetic markers within the human genome.||1||Both||Yes|
|Sten Gibson||GOped AB||Preclinical/Clinical||Läkelådan||[email protected]||Study and manipulation of joint fluid to permit cartilage regeneration||>2||Both||Maybe||This has just started and is open for different pathways to unlock secrets about fundaments for the existence of cartilage covering the bone i every joint. I recomend also Pubmed med PMID 28831830|
|Maria Genander||Genander||Preclinical||Cell and molecular biology (CMB)||[email protected]||Its is becoming clear that mechanisms important for developing tissues are often reused in cancers. Cancer stem cells drive tumor formation, analogous to how normal stem cells maintain tissues. We are characterizing transcriptional networks regulating properties of embryonic epidermal stem cells and squamous cell carcinoma cancer stem cells to identify unique and common signatures, with the long term aims of identifying novel therapeutic targets.||1-2||Both||No|
|Magdalena Paolino||Magdalena Paolino||Preclinical||Medicine Solna (MedS)||[email protected]||The Paolino laboratory is interested in exploring the functions and mechanisms of ubiquitin-dependent pathways in disease pathogenesis, particularly in metabolism, cancer and immunity (Paolino et al. Nature 2014, Suriben et al. Cell 2015, Paolino et al. J. Immunol 2011). For this project, the student will apply diverse technologies, including 3D-organoid cultures, CRISPR/Cas9 and shRNA, retroviruses, qPCR, and mouse models, to explore a novel role of ubiquitination in intestinal homeostasis and colorectal cancer.||1-2||The semester||No|